Table 1.

Effect of Reaction Conditions^a

Entry	Substrate	Ligand	Yield (%)	ee 2 (%)
1	1a	3a	30b	--
2c	1a	3a	48	--
3c	1a	3c	62	60
4c,d	1a	3c	50	89
5c,d,e	1a	3c	68	71
6	1b	3a	47	--
7	1b	3b	78	>95
8	1b	3c	64	94
9	1b	3c	47	Nd
10d	1b	3c	78	>95
11d,f	1b	3c	75	>95
12d,g	1b	3c	48	Nd
13	1b	3d	84	−89
14	1b	3e	81	−84
15d	1b	3d	78	>−95

^aGeneral conditions: 1 (0.18 mmol), 20 mol% Cu(OTf)₂, 25 mol% 3, PhCF₃ (0.1 M w/r to 1), 120 °C, 24 h, sealed tube, under Argon. MnO₂ (85% by weight, <5 m particle size) was used.

^b30% product 2a along with 30% 1a and 33% of its corresponding aldehyde.

^cAg₂CO₃ (1 equiv) was used instead of MnO₂.

^dReaction run in 1,2-dichloroethane (DCE) at 105 °C.

^eReaction run with 2,6-di-tert-butyl-4-methylpyridine instead of K₂CO₃.

^f15 mol% Cu(OTf)₂ and 19 mol% 3c were used.

^g10 mol% Cu(OTf)₂ and 12.5 mol % 3c were used. Nd = not determined.