Table 2. Hazard Ratios and 95% CIs of Incident Colorectal Cancer in the Pooled Analytic Cohort, by Quintiles of Sulfur Microbial Diet Score.

Model	Sulfur microbial diet score, HR (95% CI)						P value for trenda
	Quintile 1 (lowest)	Quintile 2	Quintile 3	Quintile 4	Quintile 5 (highest)
Colorectal cancer
Cases	650	693	642	636	596	NA
Person-years	1 083 910	1 091 687	1 072 512	1 044 147	985 792	NA
Adjusted for ageb	1 [Reference]	1.12 (1.01-1.25)	1.14 (1.02-1.27)	1.24 (1.11-1.39)	1.42 (1.27-1.59)	<.001
Multivariable adjustedc	1 [Reference]	1.10 (0.99-1.23)	1.10 (0.98-1.23)	1.16 (1.04-1.31)	1.27 (1.12-1.44)	<.001
Proximal colon cancer
Cases	264	265	238	232	201	NA
Adjusted for ageb	1 [Reference]	1.06 (0.89-1.26)	1.06 (0.88-1.26)	1.15 (0.96-1.37)	1.24 (1.03-1.50)	.02
Multivariable adjustedc	1 [Reference]	1.05 (0.88-1.25)	1.03 (0.86-1.24)	1.10 (0.91-1.33)	1.13 (0.93-1.39)	.19
Distal colon and rectal cancer
Cases	297	319	305	298	281	NA
Adjusted for ageb	1 [Reference]	1.13 (0.96-1.32)	1.17 (1.00-1.37)	1.25 (1.06-1.47)	1.40 (1.19-1.66)	<.001
Multivariable adjustedc	1 [Reference]	1.10 (0.93-1.29)	1.12 (0.95-1.32)	1.16 (0.98-1.38)	1.25 (1.05-1.50)	.02

Abbreviations: HR, hazard ratio; NA, not applicable.

^a Trend test was performed using median value of each diet score quintile as a continuous variable.

^b Models were stratified by age, questionnaire cycle, and cohort.

^c Models were stratified by age, questionnaire cycle, and cohort, and adjusted for the following covariates: race, body mass index, family history of colorectal cancer, physical activity, smoking status, smoking pack-years, menopausal hormone use (women only), aspirin use, nonsteroidal anti-inflammatory drug use, prior endoscopy, recent physical examination, and total calorie intake.