Table 2. Postsepsis Morbidity and Mortality at 12 Months, by Age Group and Severitya.
| Outcome | Survivors, % (95% CI) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| <40 y (n = 2649) | 40-65 y (n = 25 860) | 66-80 y (n = 51 787) | >80 y (n = 36 211) | Nonsevere sepsis (n = 78 667)b | Severe sepsis or septic shock (n = 37 840)b | Not treated in ICU (n = 84 269)b | Treated in ICU (n = 32 238)b | No preexisting diagnosis (n = 8622) | |
| Any new diagnosisc | 56.1 (54.2-57.9) | 72.1 (71.6-72.7) | 76.0 (75.7-76.4) | 74.7 (74.3-75.2) | 73.7 (73.4-74.0) | 75.6 (75.1-76.0) | 72.8 (72.5-73.1) | 78.3 (77.8-78.7) | 68.5 (67.5-69.5) |
| New medical diagnosis | 48.5 (46.6-50.4) | 67.2 (66.6-67.8) | 73.1 (72.7-73.5) | 72.1 (71.6-72.5) | 70.0 (69.7-70.4) | 72.8 (72.3-73.2) | 69.3 (69.0-69.6) | 75.3 (74.8-75.7) | 63.5 (62.4-64.5) |
| New psychological diagnosis | 19.5 (18.1-21.1) | 23.0 (22.5-23.5) | 18.1 (17.8-18.4) | 13.8 (13.5-14.2) | 17.4 (17.1-17.6) | 19.0 (18.6-19.4) | 16.5 (16.3-16.8) | 21.4 (21.0-21.9) | 25.0 (24.1-25.9) |
| New cognitive diagnosisd | 4.8 (4-5.7) | 10.3 (9.9-10.7) | 18.9 (18.5-19.3) | 28.5 (27.9-29.1) | 17.8 (17.4-18.1) | 19.9 (19.5-20.4) | 17.8 (17.4-18.1) | 20.2 (19.7-20.7) | 12.8 (12.1-13.6) |
| New diagnoses in 2 domains | 14.0 (12.7-15.4) | 20.7 (20.2-21.2) | 21.2 (20.8-21.5) | 20.1 (19.7-20.5) | 19.9 (19.6-20.2) | 22.0 (21.6-22.4) | 19.2 (18.9-19.4) | 24.2 (23.7-24.7) | 22.1 (21.2-23.0) |
| New diagnoses in 3 domains | 1.2 (0.9-1.7) | 3.3 (3.1-3.6) | 4.2 (4-4.4) | 3.8 (3.6-4) | 3.4 (3.3-3.6) | 4.6 (4.4-4.8) | 3.3 (3.2-3.4) | 5.2 (5.0-5.5) | 5.4 (4.9-5.9) |
| New nursing home residenced | 1.4 (1-2) | 6.7 (6.4-7.1) | 10.6 (10.4-10.9) | 19.6 (19.2-20.1) | 11.5 (11.3-11.7) | 13.1 (12.7-13.4) | 11.5 (11.3-11.8) | 13.2 (12.8-13.5) | 7.2 (6.7-7.8) |
| New nursing cared,e | 6.9 (5.9-8) | 19.9 (19.4-20.5) | 32.6 (32.1-33.1) | 47.7 (46.9-48.5) | 29.9 (29.5-30.3) | 34.8 (34.2-35.3) | 29.1 (28.7-29.5) | 36.8 (36.2-37.5) | 19.3 (18.5-20.2) |
| Mortality | 7.9 (6.9-8.9) | 21.9 (21.4-22.4) | 30.2 (29.8-30.6) | 39.4 (38.9-39.9) | 29.2 (28.9-29.5) | 33.9 (33.4-34.4) | 30.3 (30.0-30.6) | 31.8 (31.3-32.3) | 15.2 (14.4-15.9) |
| Total health care costs, €f | |||||||||
| Mean (SD) | 21 847 (49 351) | 20 586 (33 973) | 15 686 (22 778) | 9178 (12 817) | 14 372 (24 289) | 15 969 (25 610) | 13 682 (23 214) | 18 051 (28 090) | 12 583 (25 932) |
| Median (IQR) | 5391 (803 to 23 102) | 9281 (2772 to 24 840) | 8049 (2961 to 19 330) | 5107 (1797 to 11 565) | 6763 (2368 to 16 625) | 7736 (2536 to 18 933) | 6414 (2223 to 15 814) | 9146 (3100 to 21 813) | 3716 (812 to 12 696) |
Abbreviation: ICU, intensive care unit.
All International Classification of Disease–based definitions for the baseline and index hospitalization characteristics can be found in the eAppendix in the Supplement.
Differences between groups (nonsevere vs severe sepsis; non-ICU vs ICU) were statistically significant (each P < .001).
At least 1 new cognitive, psychological, or medical diagnosis in the 12 months after index hospitalization discharge.
New cognitive diagnosis, new nursing home residence, and new nursing care were determined among survivors without these in the 12 months prior to index hospitalization.
New care level according to German care level system or new nursing home residence, ranging from grade 1 (“Little impairment of independence”) to grade 5 (“Hardship cases”).
Total health care costs include cost for hospitalizations, outpatient consultations, medication, treatments (eg, physical or occupational therapy), and rehabilitation. To convert to US dollars, apply the 2017 mean exchange rate of 0.885 €/US $.26