Fig. 2.
Craniosynostosis caused by SuSC-specific disruption of Bmpr1a involves an unusual suture closure process. The control and Bmpr1aAx2 calvaria are analyzed by alizarin red (A-F) and Goldner’s trichrome (G-L) staining in whole mounts (A-F) and sections (G-L) at P0 (A, D, G-H), P7 (B, E, I-J) and P14 (C, F, K-L). Mineralization arising in the suture midline is evident between calvarial bone plates as indicated by arrowheads. Arrows indicate osteogenic fronts. Images are representatives of three independent experiments. Scale bar, 400 μm (G-L).