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. 2021 Nov 11;220(12):e202104087. doi: 10.1083/jcb.202104087

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© 2021 Perez-Vale et al.

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Figure 6. — Neither the PDZ nor the FAB domains are required for viability, but sensitized assays reveal roles in morphogenesis. (A–C) Viable homozygous adults. (D and E) Error bars represent SD. (D) Embryonic lethality, M/Z mutants. (E) Sensitized assay revealed reduced function of CnoΔPDZ and CnoΔFAB. Embryonic lethality, progeny of crosses of WT, or cno mutants heterozygous with cno^R2. cnoWT behaves like a WT allele, while cnoΔPDZ and cnoΔFAB provide less function. (F) Cuticles reveal reduced function in morphogenesis. (D–F) n indicates the total number of embryos analyzed.