Table 2.

Occurrence of cardiovascular events during 10-year follow-up, according to categories of coronary artery calcium score

CACS (Agatston units)		Event
		MACE (n = 90)	MI (n = 36)	Stroke (n = 36)	CV death (n = 34)	MI or CV death (n = 62)
0 (n = 174)	Proportion with event	5/174 (2.9%)	0	5/174 (2.9%)	0	0
	Rate per 1,000 person-years	2.96	0	2.96	0	0
	Hazard ratio*	1 (ref.)
1–100 (n = 229)	Proportion with event	19/229 (8.3%)	8/229 (3.5%)	6/229 (2.6%)	6/229 (2.6%)	13/229 (5.7%)
	Rate per 1,000 person-years	8.83	3.66	2.76	2.72	5.95
	Unadjusted hazard ratio	3.00 (1.12–8.04) p = 0.029
	Adjusted hazard ratio	2.92 (1.06–7.86) p = 0.033
101–300 (n = 131)	Proportion with event	23/131 (17.6%)	6/131 (4.6%)	12/131 (9.2%)	9/131 (6.9%)	14/131 (10.7%)
	Rate per 1,000 person-years	19.74	4.94	10.07	7.23	11.53
	Unadjusted hazard ratio	6.78 (2.58–17.83) p < 0.001
	Adjusted hazard ratio	6.53 (2.47–17.29) p < 0.001
> 300 (n = 201)	Proportion with event	43/201 (21.4%)	22/201 (10.9%)	13/201 (6.5%)	19/201 (9.5%)	35/201 (17.4%)
	Rate per 1,000 person-years	24.94	12.45	7.25	10.30	19.81
	Unadjusted hazard ratio	8.68 (3.44–21.90) p  < 0.001
	Adjusted hazard ratio	8.30 (3.28–21.00) p < 0.001

CACS = coronary arteries calcium score (Agatston units); CV = cardiovascular; MACE = major adverse cardiovascular events; MI = myocardial infarction

^*Hazard ratios are presented for MACE only due to wide confidence intervals secondary to low number of events in the individual endpoints. Adjustment was made for age, sex, duration of diabetes, insulin treatment, glycated hemoglobin, presence of retinopathy, nephropathy, neuropathy, creatinine clearance, prior CVA/TIA and medication treatment with aspirin or statin at enrolment, as well as PCE 10-year risk score (%) and MESA_{(without CACS)} 10-year risk score (%)