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. 2021 Nov 13;19:464. doi: 10.1186/s12967-021-03124-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — CircPIP5K1A contributes to cancer cell stemness by targeting miR-515-5p/YAP axis in osteosarcoma cells. A–D MG63 and 143B cells were transfected with circPIP5K1A siRNA or miR-515-5p mimic, or co-transfected with circPIP5K1A siRNA and YAP overexpression vector or miR-515-5p inhibitor. A, B The stemness was analyzed by sphere formation assays. C, D The protein levels of ALDH1 and Nanog were detected by Western blot. E The expression of Nanog was measured by immunofluorescence analysis. Mean ± SD (**P < 0.01)