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. 2021 Nov 13;19:464. doi: 10.1186/s12967-021-03124-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — The depletion of circPIP5K1A represses osteosarcoma cell growth in vivo. A–E Nude mice (n = 5) were injected with MG63 cells transfected with circPIP5K1A siRNA. The tumor xenograft was conducted in the mice. A The tumor images. B The tumor volume. C The tumor weight. D MiR-515-5p expression was measured using qPCR. E YAP protein levels were tested by Western blot analysis. F A snapshot of this study was shown. Mean ± SD (**P < 0.01)