Table 2.
VEGFR-2 and FGFR-1 biochemical and cellular potencies of compounds 6, 7, and 8
| Entry | IC50 (nM) | |||
|---|---|---|---|---|
| Kinase inhibition | Growth inhibition of HUVECs | |||
| VEGFR-2 | FGFR-1 | VEGF | FGF | |
| 6 | 57 | 100 | 17 | 21 |
| 7 | 16 | 16 | 2.1 | 4.6 |
| 8 | 53 | 220 | 27 | 130 |
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