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The activities of compounds 30–34 on aurora kinase and HCT-116 cells
| Entry | Compd | Aurora Kd (nM) | Cell IC50 (nM) | |||
|---|---|---|---|---|---|---|
| A | B | C | pHH3 (HCT-116) | Proliferation (HCT-116) | ||
| 1 | 30 | 12 | 20 | 4 | 55 | 28 |
| 2 | 31 | 7 | 4 | 5 | 190 | 75 |
| 3 | 32 | 9 | 8 | 2 | 15 | 8 |
| 4 | 33 | 12 | 5 | nd | 16 | 4 |
| 5 | 34 | 15 | 8 | nd | 44 | 5 |
