Table 2.

IVW multivariable MR for the effects of TGs on COVID-19 risk adjusted for other traits

Exposure traits	Adjustment	Outcome traits
		COVID-19 susceptibility	COVID-19 hospitalization	COVID-19 severity
		OR (95% CI), P-value	OR (95% CI), P-value	OR (95% CI), P-value
Apo-B	TG	0.966 (0.89–1.05), 0.422	0.905 (0.77–1.06), 0.228	0.954 (0.73–1.24), 0.725
TG	Apo-B	1.063 (0.98–1.15), 0.139	1.178 (1.01–1.37), 0.036	1.306 (1.06–1.60), 0.011
LDL	TG	1.017 (0.93–1.12), 0.717	0.948 (0.79–1.13), 0.558	1.036 (0.79–1.35), 0.795
TG	LDL-C	1.073 (0.99–1.16), 0.073	1.158 (1.00–1.34), 0.042	1.276 (1.05–1.55), 0.013
BMI	TG	1.130 (1.02–1.25), 0.016	1.374 (1.13–1.67), 0.001	1.404 (1.08–1.83), 0.012
TG	BMI	1.071 (0.99–1.15), 0.066	1.189 (1.04–1.36), 0.013	1.261 (1.04–1.53), 0.018

Apo-B, apolipoprotein B; BMI, body mass index; CI, confidence interval; COVID-19, coronavirus disease 2019; IVW, inverse variance weighted; LDL-C, low-density lipoprotein cholesterol; MR, Mendelian randomization; OR, odds ratio; SE, standard error; SNV, single nucleotide variant; TG, triglyceride