Fig. 2. Measles eliminates preexisting immune memory.

(A) The proportion of total epitopes detected at time 1 that were retained at time 2. One point represents one child. Bonferroni-adjusted student’s t test P values for significant differences relative to control A are shown (****P < 0.0001). (B) Probability of retaining initial antibodies at time 2 for individual pathogens per child. Each point represents a single pathogen per child. Probabilities are obtained by fitting a binomial random effects model controlling for interval duration (materials and methods). Each boxplot represents the interquartile range and median retention probabilities calculated across pathogens for a single child. Points indicate pathogen-specific retentions that are outside of the interquartile range per child. Children are rank ordered along the x axis by the median (black dot per boxplot) retention probabilities. (C) Density distribution of probabilities shown in (B), derived by collapsing all points in (B) by cohort. Bonferroni-adjusted Wilcoxon signed rank test P values for differences relative to control A are shown (***P < 0.001).