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Coronavirus entry and replication inside the host cell. (1) Spike protein on the virion attaches to the cell-surface protein (ACE2), TMPRSS2, an enzyme that helps the virion to enter. (2) RNA is released by the virion. (3) Some RNAs are translated into proteins by the cell's machinery. (4) Formation of a replication complex by some of the proteins to make more RNAs. (5) Assembling of the proteins and RNAs into a new virion in the Golgi. (6) Release of new viruses.
