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Therapies of patients with mild-to-moderate COVID-19 (PiO2/FiO2 200–350) during the first versus the second wave of the pandemic. *The use of steroids was classified in low dose and high dose of based on the cutoff of 1 mg/kg/d of methylprednisolone or equivalents (WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, JAMA. 2020;324:1330–1341). **LMWH prophylactic dose: enoxaparin 40–60 mg daily
