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Therapies of patients with severe COVID-19 (PiO2/FiO2 < 200) during the first versus the second wave of the pandemic. *The use of steroids was classified in low dose and high dose of based on the cutoff of 1 mg/kg/d of methylprednisolone or equivalents. **LMWH prophylactic dose: enoxaparin 40–60 mg daily; LMWH therapeutic dose: 40–60 mg twice daily
