Fig. 2.

In vivo biodistribution of CoviFab labelled with IRDye® 800CW in mice, after the administration of intravenous doses of 4 mg/kg at time 0 and 48 h. A: Representative images acquired at different times and observed at 800 nm (top) and pseudocolour (bottom) of ventral, lateral, and dorsal views. The arrows indicate the days when the treatments were performed. B: Biodistribution profile based on the quantitative analysis of fluorescence (RFU: relatives fluorescence units) in auricular, liver, kidney, and bladder areas (details in Fig. 1). Data are presented as mean ± standard deviations. Significant differences with vehicle control group (0) (analysis of variance, Dunnett post hoc test) are indicated (* = p < 0.05; ** = p < 0.01; *** = p < 0.001).