Fig. 5.

Ex vivo fluorescence images in mice treated with CoviFab labelled with IRDye® 800CW, after the administration of intravenous doses of 4 mg/kg at time 0 and at 48 h. A: Representative pseudocolour images of the liver, kidney, adrenal glands, digestive system, testicles, spleen, lung, heart, brain, eyes, bladder, and blood acquired from the control animals (C) and treated animals at 96 h (T96) and 144 h (T144) at necropsies. B: The fluorescence (RFU: relatives fluorescence units) was quantitatively measured in the different organs. Data are presented as mean ± standard deviations. Significant differences with vehicle control group (analysis of variance, Dunnett post hoc test) are indicated (* = p < 0.05; ** = p < 0.01; *** = p < 0.001).