Table 3.
Polysomnogram sleep metrics by prior PAP use—excluding patients with heart failure and ejection fraction ≤ 45%: median [Q1, Q3]/nominal 2-sided p-value from Wilcoxon signed-rank test for paired change from baseline to visit
| Endpoint | Prior PAP-treated group | PAP-naïve group | ||||
|---|---|---|---|---|---|---|
| Baseline (n = 35) |
1 year | Baseline (n = 38) |
1 year | |||
| Result (n = 33) |
Paired change from baseline | Result (n = 32) |
Change from baseline | |||
| Apnea-hypopnea index (events/hour) | 52 [34, 69] | 16 [10, 29] |
−30 [−45, −7] <.001 |
38 [27, 57] | 17 [7, 32] |
−17 [−39, −7] <.001 |
| Central apnea index (events/hour) | 32 [17, 50] | 3 [1, 7] |
−24 [−40, −14] <.001 |
18 [10, 35] | 1 [0, 4] |
−16 [−27, −9] <.001 |
| Obstructive apnea index (events/hour) | 2 [0, 3] | 1 [1, 4] |
0 [−1, 3] 0.391 |
2 [1, 4] | 2 [0, 11] |
1 [−2, 7] 0.252 |
| Mixed apnea index (events/hour) | 1 [0, 3] | 0 [0, 1] |
−1 [−2, −0] <.001 |
1 [0, 7] | 0 [0, 0] |
−1 [−5, 0] <.001 |
| Hypopnea index (events/hour) | 12 [2, 19] | 11 [5, 19] |
2 [−8, 7] 0.569 |
10 [5, 18] | 8 [3, 16] |
−2 [−8, 6] 0.446 |
| 4% oxygen desaturation index (events/hour) | 45 [32, 64] | 15 [8, 26] |
−28 [−42, −6] <.001 |
32 [21, 55] | 16 [6, 29] |
−18 [−32, −3] <.001 |
| Arousal index (events/hour) | 36 [24, 48] | 18 [14, 26] |
−13 [−26, −6] <.001 |
38 [27, 57] | 24 [14, 35] |
−10 [−33, −3] <.001 |
| Percent of sleep with oxygen saturation<90% (%) | 12 [2, 23] | 4 [1, 10] |
−7 [−15, −1] <.001 |
6 [1, 18] | 2 [1, 12] |
−2 [−8, 0] 0.004 |
| Percent of sleep in N1 (% of sleep) | 28 [15, 39] | 21 [13, 27] |
−7 [−18, 3] 0.025 |
28 [19, 50] | 29 [20, 44] |
−3 [−10, 4] 0.176 |
| Percent of sleep in N2 (% of sleep) | 52 [44, 63] | 58 [48, 66] |
4 [−4, 12] 0.143 |
47 [41, 58] | 52 [42, 58] |
3 [−4, 12] 0.195 |
| Percent of sleep in N3 (% of sleep) | 3 [1, 7] | 2 [0, 7] |
0 [−1, 2] 0.924 |
3 [0, 10] | 1 [0, 8] |
−1 [−4, 0] 0.010 |
| Percent of sleep in REM (% of sleep) | 11 [6, 19] | 15 [6, 21] |
3 [−5, 8] 0.445 |
10 [6, 13] | 13 [6, 21] |
2 [−3, 10] 0.083 |
| Epworth Sleepiness Scale (points) | 13 [7, 19] | 8 [5, 10] |
−4 [−9, 0] <.001 |
10 [5, 13] | 6 [4, 8] |
−3 [−7, −1] <.001 |
| Fatigue Severity Scale (points) | 5.2 [4.3, 6.2] | 4.6 [3.3, 5.7] |
−0.6 [−1.4, 0.2] 0.020 |
4.5 [3.3, 5.6] | 3.1 [2.2, 4.4] |
−0.9 [−1.8, 0.5] 0.009 |