Table 1.
Association of smoking and drinking PRS with psychiatric and behavioral traits surviving the FDR 5% threshold.
| PRS | Phenotype | Threshold | SNP N | Model 1 | Model 2 | Model 3 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R2 | Z- score | P | R2 | Z- score | P | R2 | Z- score | P | ||||
| ASI | PEITANG | 0.408 | 59,052 | 0.49% | 4.61 | 4.14E−06 | 0.44% | 4.36 | 1.31E−05 | 0.21% | 3.06 | 0.002 |
| Father_Education | 0.0016 | 897 | 0.47% | 4.57 | 5.00E−06 | 0.41% | 4.27 | 2.03E−05 | 0.28% | 3.62 | 3.04E−04 | |
| SIP019 | 0.1 | 21,081 | 0.41% | −4.2 | 2.73E−05 | 0.34% | −3.84 | 1.24E−04 | 0.15% | −2.52 | 0.012 | |
| CDD022 | 0.093 | 19,832 | 0.34% | 3.97 | 7.34E−05 | 0.28% | 3.62 | 3.03E−04 | 0.25% | 3.4 | 6.76E−04 | |
| WRAT_CR_STD | 1 | 99,097 | 0.35% | 3.89 | 1.03E−04 | 0.28% | 3.46 | 5.36E−04 | 0.05% | 1.47 | 0.142 | |
| CPD | PVRT_GENUS | 0.0013 | 1039 | 0.82% | −6.11 | 1.08E−09 | 0.72% | −5.8 | 7.20E−09 | 0.41% | −4.44 | 9.35E−06 |
| PEIT_GENUS | 4.00E−04 | 520 | 0.69% | −5.63 | 1.87E−08 | 0.49% | −4.78 | 1.83E−06 | 0.33% | −3.99 | 6.76E−05 | |
| PEIT_CR | 2.50E−04 | 413 | 0.42% | −4.37 | 1.28E−05 | 0.35% | −3.96 | 7.51E−05 | 0.28% | −3.57 | 3.66E−04 | |
| PVRT_CR | 0.0015 | 1159 | 0.31% | −4.3 | 1.77E−05 | 0.31% | −4.26 | 2.07E−05 | 0.15% | −3.09 | 0.002 | |
| SIP017 | 0.0013 | 1039 | 0.39% | 4.08 | 4.54E−05 | 0.33% | 3.82 | 1.37E−04 | 0.20% | 2.95 | 0.003 | |
| SIP018 | 0.0013 | 1039 | 0.38% | 4.04 | 5.48E−05 | 0.27% | 3.42 | 6.24E−04 | 0.16% | 2.64 | 0.008 | |
| SIP020 | 0.0013 | 1039 | 0.37% | 4 | 6.37E−05 | 0.35% | 3.92 | 8.82E−05 | 0.20% | 2.99 | 0.003 | |
| DPW | SIP023 | 0.0024 | 2025 | 0.50% | −4.66 | 3.23E−06 | 0.44% | −4.37 | 1.28E−05 | 0.36% | −4 | 6.37E−05 |
| SIP022 | 0.0059 | 3468 | 0.42% | −4.25 | 2.15E−05 | 0.35% | −3.89 | 1.03E−04 | 0.27% | −3.42 | 6.24E−04 | |
| PADT_GENUS | 5.00E−08 | 48 | 0.31% | 4.01 | 6.18E−05 | 0.28% | 3.81 | 1.43E−04 | 0.28% | 3.82 | 1.33E−04 | |
| PEDT_GENUS | 5.00E−08 | 48 | 0.31% | 4.01 | 6.18E−05 | 0.28% | 3.81 | 1.43E−04 | 0.28% | 3.82 | 1.33E−04 | |
| SIP021 | 0.0059 | 3468 | 0.37% | −4.01 | 6.24E−05 | 0.30% | −3.59 | 3.30E−04 | 0.22% | −3.12 | 0.002 | |
| OCD022 | 5.01E−05 | 299 | 0.38% | 4 | 6.42E−05 | 0.38% | 4.01 | 6.18E−05 | 0.34% | 3.8 | 1.44E−04 | |
| SIP015 | 0.0071 | 3877 | 0.37% | −3.98 | 7.03E−05 | 0.30% | −3.58 | 3.42E−04 | 0.24% | −3.22 | 0.001 | |
| SIP016 | 0.0071 | 3893 | 0.36% | −3.96 | 7.76E−05 | 0.38% | −4.06 | 4.92E−05 | 0.28% | −3.48 | 4.99E−04 | |
| PHB013 | 5.01E−05 | 299 | 0.36% | 3.94 | 8.19E−05 | 0.39% | 4.1 | 4.26E−05 | 0.32% | 3.72 | 2.02E−04 | |
| SIP024 | 0.0071 | 3893 | 0.36% | −3.91 | 9.27E−05 | 0.39% | −4.12 | 3.87E−05 | 0.30% | −3.62 | 2.99E−04 | |
| SIP025 | 0.0024 | 2025 | 0.35% | −3.9 | 9.79E−05 | 0.32% | −3.73 | 1.92E−04 | 0.27% | −3.47 | 5.27E−04 | |
| SC | PMAT_GENUS | 5.01E−05 | 73 | 0.51% | 4.94 | 8.06E−07 | 0.50% | 4.91 | 9.23E−07 | 0.46% | 4.72 | 2.47E−06 |
| SI | SUB_ALC | 0.077 | 20,981 | 0.58% | −5.31 | 1.16E−07 | 0.68% | −5.78 | 7.83E−09 | 0.90% | −6.72 | 2.04E−11 |
| SUB_COC | 0.072 | 20,123 | 0.57% | −5.27 | 1.42E−07 | 0.66% | −5.72 | 1.17E−08 | 0.89% | −6.69 | 2.58E−11 | |
| SUB_TRAN | 0.077 | 20,981 | 0.51% | −4.95 | 7.85E−07 | 0.61% | −5.44 | 5.76E−08 | 0.83% | −6.4 | 1.67E−10 | |
| age_at_cnb | 0.072 | 20,138 | 0.01% | 4.58 | 4.70E−06 | 0.02% | 5.16 | 2.56E−07 | 0.02% | 5.6 | 2.35E−08 | |
| ODD002 | 0.149 | 32,093 | 0.69% | 4.41 | 1.03E−05 | 0.74% | 4.58 | 4.65E−06 | 0.40% | 3.37 | 7.64E−04 | |
| Mother_Education | 0.081 | 21,799 | 0.44% | −4.38 | 1.22E−05 | 0.36% | −3.95 | 7.88E−05 | 0.25% | −3.35 | 8.28E−04 | |
| DEP004 | 0.01 | 6639 | 0.63% | 4.34 | 1.45E−05 | 0.57% | 4.11 | 4.04E−05 | 0.43% | 3.58 | 3.42E−04 | |
| PFMT_IFAC_RTC | 0.012 | 7229 | 0.42% | −4.3 | 1.77E−05 | 0.36% | −4 | 6.42E−05 | 0.25% | −3.33 | 8.62E−04 | |
| ADD011 | 5.01E-05 | 677 | 0.59% | 4.27 | 1.93E−05 | 0.45% | 3.74 | 1.87E−04 | 0.31% | 3.13 | 0.002 | |
| PFMT_TPRT | 0.011 | 6963 | 0.37% | −4.12 | 3.86E−05 | 0.39% | −4.21 | 2.56E−05 | 0.25% | −3.42 | 6.35E−04 | |
| SOC011 | 0.0084 | 5875 | 0.38% | −4.05 | 5.21E−05 | 0.36% | −3.94 | 8.45E−05 | 0.27% | −3.41 | 6.60E−04 | |
| MAN030 | 0.0078 | 5636 | 0.36% | −3.93 | 8.48E−05 | 0.34% | −3.83 | 1.30E−04 | 0.23% | −3.15 | 0.002 | |
The definition of the phenotype abbreviations is available in Supplementary Table S1. The results were assessed with respect to three regression models, including different sets of covariates. Model 1 covariates: 10 principal components, Sex, Age, Type of Interview, Medical Rating; Model 2 covariates: Model 1 + PRSs for smoking and alcohol traits; Model 3 covariates: Model 1 + PRSs for PGC cross-disorder, cognitive performance, educational attainment, general-risk tolerance, and household income.
ASI age of smoking initiation, CPD cigarettes per day, DPW drinks per week, SC smoking cessation, SI smoking initiation.