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. 2021 Nov 13;12(11):1082. doi: 10.1038/s41419-021-04358-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A UMAP representation of nine subgroups generated from C0. B Dotplot illustrating the representative genes across diverse cell types. C Kaplan–Meier curves for patients with high- and low-GSVA score (based on top 100 markers of S3) in GEO OC meta data sets (Log-rank p = 0.0099). D Functional analysis of each subtype is illustrated with KEGG. E Pseudotime of nine subtypes and four samples in C0 inferred by Monocle2. Each point corresponds to a single cell. Clusters or samples information are shown. F Expression of PEG10 was mapped to the single-cell trajectory plot. Colour from grey to red indicates relative expression levels from low to high. G Violin plots illustrating the mRNA levels of PEG10 and SOX2 in samples based on cells in S3. H Heatmap of selected ligand–receptor interactions between diverse cell types and subtypes of C0. Point size indicates p value (CellPhoneDB). Colour indicates the mean expression level of ligand and receptor (Mol1/2).