Fig. 6.

The mechanism of Traditional Chinese medicines (TCMs) against COVID-19. Keguan-1 can “resist foreign aggression” by directly inhibiting SARS-CoV-2 and the inflammation caused by the virus and “pacify the interior” by regulating pulmonary vascular endothelial injury, and then realise the comprehensive treatment of patient with COVID-19 via the effect on both the pathogen and host, which is the unique advantage and characteristic of TCMs in preventing and treating new complex diseases. The solid red line represents the regulation of Keguan-1 on pulmonary vascular endothelial injury and cytokine storm, and the red dotted line represents the potential inhibition of Keguan-1 on the binding of SARS-CoV-2 S protein to host ACE2. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)