Table 3.

Cox regression analyses for the association between TyG-BMI and incident pre-diabetes in different models

TyG-BMI	HR, 95% CI
	Unadjusted Model	Model I	Model II	Model III
WHO
Multivariable Analysis (HR Per SD increase)	1.89 (1.85, 1.94)	1.42 (1.38, 1.47)	1.39 (1.32, 1.47)	1.40 (1.32, 1.47)
TyG-BMI quartile
Q1	Ref	Ref	Ref	Ref
Q2	2.56 (2.21, 2.97)	1.60 (1.38, 1.86)	1.59 (1.30, 1.96)	1.60 (1.30, 1.96)
Q3	4.83 (4.21, 5.54)	2.18 (1.89, 2.52)	2.17 (1.78, 2.65)	2.17 (1.78, 2.65)
Q4	8.93 (7.84, 10.19)	2.96 (2.57, 3.42)	2.77 (2.25, 3.40)	2.77 (2.26, 3.41)
P-trend	< 0.0001	< 0.0001	< 0.0001	< 0.0001
ADA
Multivariable Analysis (HR Per SD increase)	1.54 (1.52, 1.56)	1.27 (1.24, 1.29)	1.23 (1.18, 1.27)	1.23 (1.18, 1.27)
TyG-BMI quartile
Q1	Ref	Ref	Ref	Ref
Q2	1.74 (1.63, 1.86)	1.34 (1.25, 1.43)	1.36 (1.23, 1.50)	1.36 (1.23, 1.49)
Q3	2.66 (2.50, 2.83)	1.70 (1.59, 1.81)	1.56 (1.41, 1.71)	1.56 (1.41, 1.71)
Q4	3.86 (3.64, 4.10)	2.03 (1.90, 2.17)	1.82 (1.63, 2.02)	1.81 (1.63, 2.02)
P-trend	< 0.0001	< 0.0001	< 0.0001	< 0.0001

Abbreviations: TyG-BMI triglyceride glucose-body mass index, HR hazard ratios, CI confidence, ADA American Diabetes Association, WHO World Health Organization

WHO: Model I adjusted for age, SBP, DBP, FPG, ALT and HDL-C; Model II adjusted for age, sex, SBP, DBP, FPG, TG, HDL-C, LDL-C, ALT, AST, BUN, Cr, drinking status and smoking status. Model III adjusted for age, sex, SBP, DBP, FPG, TG, HDL-C, LDL-C, ALT, AST, BUN, Cr, drinking status, smoking status, height and family history of diabetes

ADA: Model I adjusted for age, SBP, DBP, FPG, ALT and HDL-C; Model II adjusted for age, sex, SBP, DBP, FPG, TG, HDL-C, LDL-C, ALT, AST, BUN, Cr, smoking status, height and drinking status. Model II adjusted for age, sex, SBP, DBP, FPG, TG, HDL-C, LDL-C, ALT, AST, BUN, Cr, smoking status, height, drinking status and family history of diabetes