Table 5.
Stratified associations between TyG-BMI and pre-diabetes by age, sex, BMI and family history of diabetes
| Subgroup | WHO | P-value | P-interaction | ADA | P-value | P-interaction |
|---|---|---|---|---|---|---|
| adjusted HR (95% CI) | adjusted HR (95% CI) | |||||
| Age (years) | < 0.0001 | < 0.0001 | ||||
| 18–29 | 1.50 (1.29, 1.75) | < 0.0001 | 1.34 (1.25, 1.43) | < 0.0001 | ||
| 30–39 | 1.62 (1.52, 1.73) | < 0.0001 | 1.35 (1.31, 1.40) | < 0.0001 | ||
| 40–49 | 1.58 (1.48, 1.69) | < 0.0001 | 1.35 (1.31, 1.40) | < 0.0001 | ||
| 50–59 | 1.37 (1.29, 1.45) | < 0.0001 | 1.23 (1.18, 1.28) | < 0.0001 | ||
| 60–69 | 1.21 (1.12, 1.29) | < 0.0001 | 1.08 (1.03, 1.13) | 0.0031 | ||
| ≥ 70 | 1.19 (1.08, 1.32) | < 0.0001 | 1.10 (1.02, 1.17) | 0.0086 | ||
| Sex | 0.0182 | < 0.0001 | ||||
| Women | 1.49 (1.41, 1.57) | < 0.0001 | 1.40 (1.35, 1.44) | < 0.0001 | ||
| Men | 1.38 (1.33, 1.44) | < 0.0001 | 1.18 (1.15, 1.20) | < 0.0001 | ||
| BMI (kg/m2) | < 0.0001 | < 0.0001 | ||||
| < 18.5 | 1.43 (0.47, 4.32) | 0.5252 | 1.93 (1.25, 2.99) | 0.0030 | ||
| ≥ 18.5, < 24 | 1.84 (1.66, 2.04) | < 0.0001 | 1.51 (1.44, 1.59) | < 0.0001 | ||
| ≥ 24, < 28 | 1.34 (1.22, 1.46) | < 0.0001 | 1.26 (1.19, 1.33) | < 0.0001 | ||
| ≥ 28 | 1.30 (1.18, 1.43) | < 0.0001 | 1.15 (1.07, 1.23) | 0.0001 | ||
| Family history of diabetes | 0.0625 | 0.4701 | ||||
| Yes | 1.20 (0.99, 1.44) | 0.0576 | 1.31 (1.19, 1.45) | < 0.0001 | ||
| No | 1.43 (1.38, 1.48) | < 0.0001 | 1.27 (1.24, 1.29) | < 0.0001 |
Abbreviations: BMI body mass index, TyG-BMI triglyceride glucose-body mass index, HR hazard ratios, CI confidence, ADA American Diabetes Association, WHO World Health Organization
The model adjusted for age, SBP, DBP, FPG, ALT and HDL-C;
Note: For age stratified analysis, the stratification variable was omitted from the model