Table 4.
Clinical and laboratory features and clinical outcome of 501 MERS-CoV patients by gender, Saudi Arabia, 2014-20191
Female | Male | P-value | |
---|---|---|---|
Hematology (reference value), median (IQR) | |||
WBC (4.0-11.0) | 6.9 (4.6-9.4) | 5.7 (3.9-8.8) | 0.0143 |
Hgb (13.5-175) | 12.5 (9.9-14.1) | 13.9 (11.3-15.3) | <0.001 |
Neutrophil (1.50-7.8) | 4.3 (2.7-6.4) | 4.0 (2.4 - 6.7) | 0.29 |
Platelets (150-450) | 251 (181 - 306) | 195 (133-249) | <0.001 |
Blood Chemistry, median (IQR) | |||
Creatinine (62-115) | 56 (64-78.8) | 77 (67.8 -129.7) | <0.001 |
Albumin (32-46) | 33(28-40) | 31 (25-37) | 0.003 |
AST(5-34) | 39 (24-90) | 72.5 (35-118) | <0.001 |
ALT (5-55) | 24 (14-53) | 43 (24-84) | <0.001 |
Bilirubin (3.4-20.5) | 7.7 (5.6-11.3) | 10.1 (7-15.6) | <0.001 |
LDH (125-243) | 477 (216-603) | 546 (375-821) | 0.04 |
Microbiology and culture positive, number of patients (%) | |||
Microbiology test, | 44 (35.2) | 90 (36.4) | 0.81 |
Blood Culture | 26 (18.7) | 90 (29.1) | 0.02 |
Urine Culture | 25 (18.1) | 80 (26.0) | 0.07 |
Respiratory culture | 25 (18.0) | 84(27.4) | 0.03 |
Other culture | 22 (16.1) | 88 (29.0) | 0.004 |
Complications, number of patents (%) | |||
Chest x-ray, positive | 75 (52.8) | 197 (69.1) | 0.001 |
Acute lung Injury | 7 (16.7) | 24 (16.11) | 0.93 |
Acute renal injury | 1 (2.4) | 5 (3.4) | 0.74 |
Pneumonia | 12 (27.9) | 39 (26.2) | 0.82 |
Pleural effusion | 2 (4.7) | 8 (5.4) | 0.88 |
Cardiac arrest | 5 (11.9) | 18 (12.2) | 0.96 |
Seizure, stroke, or shock | 3 (7.1) | 6 (4.1) | 0.41 |
Other | 14 (32.3) | 14 (29.9) | 0.74 |
No complications | 12 (27.9) | 59 (38.6) | 0.20 |
Admitted to, number of patients (%) | |||
Intensive care unit | 39 (25.2) | 130 (37.6) | 0.01 |
Ward | 116 (74.8) | 216 (62.4) | 0.01 |
Duration of hospital stay, median (IQR) | |||
16 (11-28) | 19 (14-30) | 0.16 | |
Clinical outcome, number of patients (%) | |||
Died | 24 (15.5) | 82 (23.7) | 0.04 |
Discharged | 124 (80.0) | 248 (71.7) | 0.05 |
Transferred | 3 (1.9) | 8 (2.3) | 0.79 |
1Patients admitted to one of the four MERS-CoV referral hospitals in Saudi Arabia.2Denominator for laboratory and other investigations vary. AST, Aspartate Aminotransferase; ALT, Alanine Aminotransferase; LDH, lactate dehydrogenase