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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Prog Retin Eye Res. 2020 Sep 18;82:100903. doi: 10.1016/j.preteyeres.2020.100903

Figure 4. HG-induced excess ECM promotes apoptosis.

Figure 4.

(A) Representative images show RRECs plated on HG-matrix and grown in N condition exhibit increased number of apoptotic cells (red) compared to those plated on N-matrix and grown in N condition. Cells exposed to hydrogen peroxide (H2O2) served as positive control. (B) Bar graph shows cumulative data indicating that ECM produced by cells grown in HG condition (HG-matrix) is capable of promoting apoptosis in cells grown in N medium. Cells exposed to mannitol exhibited no difference in apoptosis compared to cells grown in N medium. *p<0.05; n=6.