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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Prog Retin Eye Res. 2020 Sep 18;82:100903. doi: 10.1016/j.preteyeres.2020.100903

Figure 6. Effect of As-Coll IV and As-FN oligos on Coll IV and FN immunostaining in RRECs.

Figure 6.

Immunohistochemical analysis show efficacy of (A) AS-Col oligos and (B) AS-FN oligos in reducing Col IV and FN levels, respectively, in RRECs grown in HG condition. Corresponding bright-field image is shown below each FITC-labeled photomicrograph. Bar graphs of cumulative data show AS-Col-oligos and AS-FN-oligos downregulate (C) Coll IV and (D) FN, respectively. Data is presented as mean ± standard deviation; *p<0.05. N: normal media; HG: high glucose media; As-FN: HG media + antisense FN oligos; As-Col: HG media + antisense Col IV oligos; HG+Ran: HG medium + random oligos; n=6.