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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Prog Retin Eye Res. 2020 Sep 18;82:100903. doi: 10.1016/j.preteyeres.2020.100903

Figure 9. A schematic illustration showing major steps in retinal neovascularization.

Figure 9.

This multi-step process is hypoxia-driven and involves endothelial cell participation, local BM dissolution, endothelial cell sprouting, ECM synthesis, ECM assembly, BM maturation, and neovessel formation.