Table 1.

Diabetes-induced changes in ECM component levels associated with BM thickening

ECM Component	Level	Species	References
Fibronectin	Increased	Human	(Ljubimov et al., 1996; Ljubimov et al., 1998; Monnier et al., 1999; Monnier et al., 1986; Nwomeh et al., 1998; Risteli et al., 1987; Roux et al., 1977; Roy et al., 1996; Salmela et al., 1989)
Laminin-111 (α1, β1, γ1)	Increased	Human, Rat	(Bek and Ledet, 1996; Das et al., 1990)
Vitronectin	Increased	Human	(Bek and Ledet, 1996; Weller et al., 1991)
Collagen type I	Increased	Human	(Salmela et al., 1989)
Collagen type III	Increased	Human	(Ljubimov et al., 1998; Salmela et al., 1989)
α1 Collagen type IV	Increased	Human, Mouse, Rat	(Cooper et al., 1998; Das et al., 1990; Ljubimov et al., 1996; Rasmussen and Ledet, 1993; Roy et al., 1994; Rumble et al., 1998)
α2 Collagen type IV	Increased	Human, Rat	(Ljubimov et al., 1996)
Collagen type V	Increased /Unchanged	Human	(Labat-Robert and Robert, 1988; Rasmussen and Ledet, 1993; Salmela et al., 1989)
Collagen type VI	Increased	Human, Rat	(Bek and Ledet, 1996; Shinoda, 1992; Spiro and Crowley, 1993)
Tenascin	Increased	Human	(Monnier et al., 1999; Roux et al., 1977; Salmela et al., 1989)
Chondroitin sulfate	Decreased/ Increased	Human	(Anderson, 1993; Hagedorn et al., 1993)
Hyaluronic acid	Increased	Human	(Brenner, 1994)
Heparan sulfate	Increased/Unchanged/Decreased	Human, Rat	(Anderson, 1993; Chowdhury et al., 1995; Das et al., 1990; Huijberts et al., 1994; Monnier et al., 1999; Nakamura et al., 1993)