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. 2021 Nov 10;13:8435–8443. doi: 10.2147/CMAR.S256091

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© 2021 Zhang et al.

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CircPTCD3 directly targets miR-198 in breast cancer cells. (A) The seed sequence of circPTCD3 that binds to miR-198 was showed, the sequences mutated were marked in red. (B) Luciferase reporter assay was carried out in breast cancer cell transfected with miR-198 mimic and the mimic control along with the reporter vector containing wild or mutant type of binding sequence of circPTCD3. (C) The level of miR-198 after different treatment was evaluated using qPCR. (D and E) RNA pull down was carried out using specific probe for circPTCD3 ormiR-198 respectively labeled by biotin. (F) Pearson analysis was performed to investigate the correlation between circPTCD3 and miR-198. n=6, *P< 0.05, compared with the biotin-nc, control probe, si-nc and control+wt group. ^#P < 0.05, compared with the vector group.