Fig. 3.

Quantitative analysis of the extracted brain. The voxel-wise T test successfully identified the metastatic lesions in the brain at three of four subjects in the case group (uncorrected P < 0.001). The graphics on the left side show the brain regions that show hypometabolism compared to the control group. The image on the right side shows the corresponding FDG-PET image. a, b, c In all of the three successful cases, the analysis revealed hypometabolic lesions due to edematous change around the lesion. d In the other case with unsuccessful result, the statistical analysis showed diffuse hypometabolism in frontoparietal lobe, instead of focal metabolic defect at the metastatic site