Table 3.

Multivariable analysis of predictive factors of overall survival in patients with multiple bilobar metastases after propensity score matching (simultaneous vs. staged groups)

Parameter	p-Value	HR (95% CI)
Liver-first vs. primary-first
Surgical strategy
Liver-first vs. primary-first	0.017	1.667 (1.094–2.545)
Age
> 70 vs. ≤ 70 years	0.733	1.092 (0.657–1.817)
Year of resection
2000–2006		1
2007–2011	0.558	0.806 (0.392–1.658)
2012–2017	0.344	0.686 (0.314–1.498)
Primary tumor site
Left colon		1
Right/transverse colon	0.483	0.802 (0.434–1.483)
Rectum	0.532	1.146 (0.747–1.759)
N status primary tumor
N+ vs. N0	0.283	1.266 (0.823–1.948)
Number of metastases > 3
Y vs. N	0.900	0.975 (0.656–1.448)
Metastases size > 50 mm
Y vs. N	0.533	0.876 (0.576–1.329)
Preoperative chemotherapy
Y vs. N	0.594	0.861 (0.497–1.492)
Complete resectiona
R1 vs. R0	0.020	1.639 (1.080–2.488)
Associated intraoperative thermal ablation
Y vs. N	0.396	1.206 (0.783––1.857)

Liver-first vs. simultaneous
Surgical strategy
Liver-first vs. simultaneous	0.003	2.278 (1.319–3.937)
Age
> 70 vs. ≤ 70 years	0.703	1.137 (0.587–2.202)
Year of resection
2000–2006		1
2007–2011	0.843	1.099 (0.431–2.800)
2012–2017	0.867	0.911 (0.305–2.720)
Primary tumor site
Left colon		1
Right/transverse colon	0.938	0.971 (0.460–2.050)
Rectum	0.707	0.889 (0.481–1.642)
N status primary tumor
N+ vs. N0	0.068	1.860 (0.955–3.621)
Number of metastases > 3
Y vs. N	0.693	1.124 (0.630–2.004)
Metastases size > 50 mm
Y vs. N	0.944	1.020 (0.585–1.780)
Preoperative chemotherapy
Y vs. N	0.919	0.964 (0.473–1.964)
Complete resectiona
R1 vs. R0	0.616	0.832 (0.405–1.707)
Associated intraoperative thermal ablation
Y vs. N	0.432	1.266 (0.703–2.281)

HR hazard ratio, CI confidence intervals, Y yes, N no

^aR0/R1 resection refers to the surgical margin of liver resection