Table 4.

Cox regression analysis (adjusting PSA and pathological T stage and PSM)

	Univariable analysis		Multivariable analysis
	HR (95% CI)	p-Value	HR (95%CI)	p-value
Biochemical recurrence-free survival
GG 4 Reference GS 3 + 5		0.007		0.03
GS 4 + 4	1.44 (1.13–1.88)	0.003	1.43 (1.12–1.86)	0.005
GS 5 + 3	1.78 (1.07–2.84)	0.03	1.38 (0.83–2.20)	0.21
Reference GS 4 + 4
GS 5 + 3	1.23 (0.78–1.84)	0.35	0.97 (0.61–1.45)	0.89
Overall survival
GG 4 Reference GS 3 + 5		0.32		0.25
GS 4 + 4	1.52 (0.89–2.82)	0.13	1.65 (0.95–3.16)	0.08
GS 5 + 3	1.56 (0.44–4.43)	0.45	1.49 (0.42–4.31)	0.50
Reference GS 4 + 4
GS 5 + 3	1.03 (0.32–2.45)	0.95	0.91 (0.28–2.16)	0.84
Cancer-specific survival
GG 4 Reference GS 3 + 5		0.61		0.53
GS 4 + 4	1.48 (0.65–4.27)	0.38	1.51 (0.66–4.35)	0.36
GS 5 + 3	0.93 (0.05–5.75)	0.94	0.71 (0.04–4.44)	0.75
Reference GS 4 + 4
GS 5 + 3	0.63 (0.04–2.85)	0.62	0.47 (0.03–2.16)	0.40

CI confidence interval, GG grade group, GS Gleason score, HR hazard ratio, PSA prostate-specific antigen, PSM positive surgical margin

Bold p values are considered statistically significant (p value < 0.05)