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. 2021 Nov 1;8:743988. doi: 10.3389/fmed.2021.743988

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Copyright © 2021 Yin, Dellicour, Daubie, Franco, Wautier, Faes, Van Cauteren, Nymark, Hens, Gilbert, Hallin and Vandenberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ct evolution by age classes with comparison to the estimated prevalence: evolution of the daily 14-day median Ct values obtained using the Abbott RealTime SARS-CoV-2 assay from April 1, 2020, to May 15, 2021 (LHUB-ULB, Brussels region, Belgium). Reddish areas surrounding solid red curves indicate the 95% confidence interval (CI) obtained by bootstrapping method associated with daily estimates of median Ct values. Those curves are superimposed on the daily prevalence of COVID-19 infected people (proportion of infected vs. Belgian demographic data) as estimated by the age-structured extended SEIR-type mathematical model. Solid grey curves indicate the 95% CI obtained by Bayesian analysis. Full data figure in Supplementary Material.