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. 2021 Nov 1;12:769647. doi: 10.3389/fphar.2021.769647

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Copyright © 2021 Zhu, Wang, Zou, Xu, Zhang, Chen, Chen, Zhang, Wang, Ding and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Avasimibe inhibits GC cell growth and metastasis. (A) Molecular structure of avasimibe. (B,C) Relative cell viability was measured by CCK-8 assay after avasimibe treatment for 24 h at multiply concentrations (0, 1, 2, 5, 10, 20, 40, and 100 μM). (D) Representative images of colony formation assay in BGC-823 and MGC-803 cells after avasimibe treatment (upper panel); the quantitative results were shown (lower panel). (E) Transwell assay in MGC-803 cells after avasimibe treatment. Representative images of migrated and invaded GC cells in each group were shown in the left panel, and the quantitative results were shown in the right panel. Scale bars: 100 µm.