TABLE 3.

Summary of intervening measure. Current interventions are mainly antioxidants, ACER/AEB/BB and new material combination drugs. Antioxidants are made up of Probucol, Ranolazine, flaxseed (FLX), alpha-linolenic acid (ALA), secoisolariciresinol diglucoside (SDG), the antioxidant coenzyme Q (10) and nanoemulsion (NES). The possible mechanism is mainly antioxidant effect. The drugs mainly affected reactive oxygen species (ROS) accumulation to inhibit of cell death.

Types	Drugs	Test subjects	Function	References
Antioxidant	Probucol	Rats	ROS↓/Myocardial remodeling↓	PMID:21353471
	Ranolazine	Mice	MMP2/Capase3↓	PMID:29467663
	FLX/ALA/SDG	Mice	Antioxidant	PMID: 32510147
	Q(10)+NEs	Humans	LTB4/NF-κB/IL-6↓	PMID: 32764923
ACER/ARB/BB	ACEI/ARB	—	RASS↓/Myocardial remodeling↓	PMID: 32777728
	BB	—	Sympathetic nervous↓	PMID: 32777728
	BB	Mice	Sirtuin-3↓/ROS↓	PMID: 33529501
	Statin	—	GS-SG↓/ROS↓	PMID: 28622591
	Lipidosome	Cells/Humans	Cardiotoxicity↓	PMID: 26759238