TABLE 1.
Gene ontology enrichment analysis of 15 subnetworks.
| Biological Processes | FE a | p-value | Cellular Components | FE a | p-value | Molecular Functions | FE a | p-value |
|---|---|---|---|---|---|---|---|---|
| Sodium ion transport | 16.6 | 1.8E-05 | Node of Ranvier | 59.6 | 1.4E-06 | Protein binding | 1.3 | 4.9E-08 |
| Nuclear division | 4.0 | 4.8E-03 | Extracellular matrix | 4.4 | 2.0E-05 | Growth factor binding | 9.1 | 6.7E-05 |
| Signaling | 2.0 | 5.8E-03 | Anchoring junction | 3.3 | 2.0E-04 | Sodium channel activity | 18.5 | 8.8E-05 |
| Cell cycle | 3.1 | 8.5E-03 | Cytoplasm | 1.3 | 3.4E-04 | Voltage-gated sodium channel activity | 27.2 | 2.5E-04 |
| Cell communication | 1.9 | 1.0E-02 | Main axon | 12.3 | 3.9E-04 | Small molecule binding | 2.0 | 6.5E-04 |
| Cellular response to stimulus | 1.8 | 1.1E-02 | Cell-cell contact zone | 11.0 | 5.9E-04 | Cytoskeletal protein binding | 2.7 | 1.0E-03 |
| Mitotic cell cycle | 3.8 | 1.2E-02 | Cell junction | 2.1 | 1.1E-03 | ATP binding | 2.2 | 2.8E-03 |
| Biological regulation | 1.5 | 1.4E-02 | Early endosome | 3.8 | 2.6E-03 | Kinase binding | 2.7 | 4.2E-03 |
| Regulation of cell communication | 2.4 | 1.8E-02 | Cell-cell junction | 3.3 | 3.0E-03 | Receptor ligand activity | 3.0 | 1.0E-02 |
| Cell surface receptor signaling pathway | 2.3 | 1.9E-02 | Cytoskeleton | 1.9 | 3.7E-03 | Signaling receptor activator activity | 2.9 | 1.1E-02 |
a
FE, Fold Enrichment is calculated by dividing the number of genes in 15 subnetworks implicated in each GO term by the expected number.