Table 1.

Univariate and Multivariate Analyses of Survival in TNBC Patients of TCGA and SYSUCC Cohort

Variables	Univariate Analysis			Multivariate Analysis
	HR	95% CI	P value	HR	95% CI	P value
TCGA
Overall survival
Age	0.980	0.927–1.035	0.461
Menopause status	1.073	0.541–2.128	0.840
History other malignancy	4.966	0.594–41.553	0.139
Surgical procedure	1.149	0.623–2.119	0.658
Primary site	0.273	0.056–1.321	0.107
TNM stage	10.439	2.464–44.216	0.001	11.819	2.730–51.170	0.001
ARNTL2	1.159	1.012–1.329	0.033	1.166	1.020–1.333	0.024
Relapse-free survival
Age	0.991	0.948–1.036	0.692
Menopause status	0.987	0.561–1.737	0.964
History other malignancy	2.277	0.295–17.547	0.430
Surgical procedure	0.924	0.547–1.560	0.767
Primary site	0.297	0.082–1.079	0.065
TNM stage	7.391	2.468–22.130	0.000a	8.524	2.798–25.971	0.000a
ARNTL2	1.130	1.000–1.276	0.050	1.148	1.021–1.291	0.021
SYSUCC cohort
Overall survival
Age	1.041	1.011–1.072	0.007	1.039	1.007–1.072	0.016
Surgical procedure	1.306	0.460–3.705	0.616
Primary site	0.822	0.437–1.545	0.542
Radiotherapy	1.223	0.645–2.321	0.537
Chemotherapy	1.552	0.649–3.710	0.323
TNM stage	3.036	1.778–5.183	0.000a	4.148	1.992–8.635	0.000a
ARNTL2	4.247	1.736–10.390	0.002	2.520	1.023–6.209	0.044
Relapse-free survival
Age	1.020	0.979–1.062	0.347
Surgical procedure	0.545	0.073–4.095	0.556
Primary site	0.670	0.286–1.569	0.357
Radiotherapy	2.498	0.974–6.407	0.057
Chemotherapy	1.715	0.506–5.809	0.386
TNM stage	6.107	2.704–13.794	0.000a	8.965	2.868–28.020	0.000a
ARNTL2	4.993	1.460–17.070	0.010	3.421	1.024–11.428	0.046

Note: ^aP < 0.001.

Abbreviations: HR, hazard ratio; CI, confidence interval.