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Comparison of properties of different costimulation 4-1BB versus CD28 in CAR-T cell.
| Property | 4-1BB | CD28 |
|---|---|---|
| Expansion ability | Low | High |
| Anti-tumor response | Persistent | Rapid |
| Susceptibility to exhaustion | Low | High |
| Phenotype formation | Memory phenotype | Effector phenotype |
| Metabolic type | Fatty acid oxidative metabolism | Glycolytic metabolism |
| Overall efficacy | Superior | Inferior |
