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. 2021 Nov 1;9:720536. doi: 10.3389/fcell.2021.720536

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Copyright © 2021 Borges, Link, Engstler and Jones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic overview of the life cycles of human-infective trypanosomatids together with their most abundant GPI-anchored molecules. (A) Trypanosoma brucei, (B) Trypanosoma cruzi, and (C) Leishmania. The replicative stages are indicated by a circular arrow (orange). GPI-anchored surface molecules: variant surface glycoprotein (VSG), transferrin receptor (TfR), GP63, procyclin, trans-sialidase (TS), brucei alanine rich protein (BARP), mucin, glycoinositolphospholipid (GIPL), mucin-associated surface protein (MASP), lipophosphoglycan (LPG), proteophosphoglycan (PPG).