TABLE 3.

Comparison of the final PK parameter estimates between non-CRRT and CRRT groups ^a .

Parameter	Non CRRT	CRRT	p-value
CL	8.57 (6.56–13.4)	6.03 (5.56–7.18)	0.0585 c
VC (L)	13.3 (9.24–16.3)	21.7 (12.5–29.7)	0.2349 c
VP (L)	12.6 (11.2–15.3)	13.3 (12.0–17.0)	0.4202 b
VSS (L)	25.0 (20.4–32.3)	35.4 (29.6–42.4)	0.0529 c

^aAbbreviations: CRRT, continuous renal replacement therapy; CL, total clearance; V_C, central volume of distribution; V_P, peripheral volume of distribution; Q, intercompartmental clearance between V_C and V_P.

^bindependent t-test.

^cWilcoxon rank-sum test.