TABLE 2.

Paired t-tests between patients and controls for relative proton densities measured in brain hemispheres contralateral or ipsilateral to the more affected body side as indicated.

Region of Interest		Ipsilateral					Contralateral
	N 1	Patient		Control		p	Patient		Control		p
		Mean	SD	Mean	SD		Mean	SD	Mean	SD
Prefrontal Subcortical Area	19	49.78	3.72	47.14	4.99	0.07	50.47	3.14	46.77	3.74	0.0024**
Subcortical Primary Motor Area	20	44.02	2.85	46.88	4.35	0.011*	44.63	3.45	44.98	3.53	0.78
Supplementary Motor Area	20	50.23	4.09	50.10	6.22	0.92	53.13	5.05	50.76	5.58	0.11
Centrum Semiovale	20	42.78	2.39	44.68	2.91	0.011*	42.55	3.20	44.37	2.76	0.06
Splenium Corporis Callosi	20	35.28	3.42	38.66	3.24	0.0002**	35.16	2.83	39.07	3.49	0.00003**
Nucleus Caudatus	20	51.46	3.48	54.70	3.28	0.0018**	50.88	3.28	55.02	3.85	0.0013**
Putamen	20	50.40	4.30	54.07	3.63	0.002**	51.06	2.55	54.44	3.61	0.0016**
Globus Pallidus	20	41.63	3.70	45.22	3.27	0.0009**	41.26	3.34	44.32	3.34	0.0154*
Thalamus	20	43.46	3.21	48.79	4.27	0.00002**	43.32	2.92	49.14	3.53	0.00002**
Mesencephalon	20	36.35	3.09	40.10	4.39	0.0023**	36.22	2.86	39.96	3.80	0.0041**
Upper Pons	20	30.81	3.24	33.01	3.07	0.0182*	30.99	2.16	33.12	2.66	0.0062**
Lower Pons	20	33.03	4.30	35.46	3.57	0.0174*	32.84	2.71	35.69	3.17	0.0052**
Cerebellar White Matter	20	34.79	3.54	35.32	3.77	0.57	35.08	2.05	35.51	3.58	0.57
Cerebellar Posterior Lobe	20	49.35	5.10	51.05	3.57	0.18	49.76	4.63	48.95	5.60	0.58

¹Number of patient-control pairs.

**Significant after correction for multiple comparisons by using false-discovery rate (FDR).

*p < 0.05 but not significant after FDR correction.