TABLE 6.

Correlations of MDS-UPDRS to significant changes of relative proton density in respect to the most affected body side of the patients estimated by Spearman’s correlation test¹.

Clinical scores	Ipsilateral
		Splenium Corporis Callosi		Nucleus Caudatus		Putamen		Globus Pallidus		Thalamus		Mesencephalon
	N	R	p	R	p	R	P	R	p	R	p	R	p
UPDRS I	20	–0.072	0.763	–0.179	0.449	–0.165	0.487	–0.160	0.499	–0.062	0.795	–0.068	0.775
UPDRS II	20	–0.053	0.824	–0.232	0.326	–0.273	0.244	–0.130	0.584	0.033	0.889	0.108	0.650
UPDRS III	20	–0.109	0.649	0.059	0.805	0.319	0.170	0.391	0.088	0.279	0.234	0.121	0.612
UPDRS IV	20	–0.084	0.725	–0.156	0.511	–0.270	0.249	–0.288	0.217	0.102	0.668	0.038	0.875
UPDRS	20	–0.211	0.371	–0.149	0.530	0.001	0.997	0.127	0.595	0.201	0.396	0.098	0.681
	Contralateral
		Prefrontal Subcortical Area		Splenium Corporis Callosi		Nucleus Caudatus		Putamen		Thalamus		Mesencephalon		Upper Pons		Lower Pons
	N	R	p	R	p	R	P	R	p	R	p	R	p	R	p	R	p
UPDRS I	20	–0.458	0.042*	–0.170	0.473	–0.372	0.106	–0.335	0.148	–0.234	0.321	–0.202	0.393	–0.110	0.645	–0.085	0.722
UPDRS II	20	–0.055	0.819	–0.174	0.463	–0.492	0.028*	–0.357	0.123	–0.323	0.164	0.030	0.902	–0.147	0.535	–0.036	0.882
UPDRS III	20	–0.068	0.776	0.132	0.579	0.051	0.830	–0.187	0.430	0.048	0.840	0.027	0.910	0.086	0.720	0.035	0.885
UPDRS IV	20	0.208	0.379	–0.206	0.385	–0.335	0.149	–0.308	0.187	–0.221	0.350	0.020	0.932	–0.020	0.932	–0.117	0.622
UPDRS	20	–0.149	0.530	–0.156	0.511	–0.317	0.174	–0.333	0.151	–0.164	0.489	–0.069	0.771	–0.014	0.952	0.005	0.982

¹12 patients with more affected right body side and 8 with more affected left body side.

**Significant after correction for multiple comparisons by using false-discovery rate (FDR).

*p < 0.05 but not significant after FDR correction.

Hence, only regions with significant alterations in relative proton density were used for correlational analysis.