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Interaction between thymic B cells and CD4 SP thymocytes. In the thymic medulla, B cells present self-antigen to CD4 SP thymocytes through MHC-II and engagement of CD40/CD40L. The interaction between both cells leads to 1) clonal deletion or generation of thymic regulatory T cells (Treg) and 2) is required for maintaining normal thymic B cell numbers and acquisition of a thymic resident B cell phenotype.
