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. 2021 Nov 1;11:744940. doi: 10.3389/fonc.2021.744940

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Copyright © 2021 Ke, Chen, Su, Chen, Lei, Xia, Wei, Zhang, Dong, Liu and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of genes potentially related to autophagy and drug resistance in ovarian cancer (OC). (A) The 131 overlapping genes involved in autophagy and drug resistance were retrieved from three independent databases. A total of 786 and 1086 autophagy-related genes were retrieved from database Autophagy DB and Thanatos, respectively. 868 genes related to OC drug resistance and autophagy were selected through text mining conducted by Coremine (P < 0.05); (B) Fourteen of the above 131 genes were significantly dysregulated in chemoresistant OC tissues (Resistant, n=90) compared with the sensitive tissues (Sensitive, n=197) according to the TCGA ovarian cohort (*P < 0.05; **P < 0.01).