TABLE 2.
Top significantly enriched KEGG signaling pathways in NSCs of LPS-induced depression mice treated with luteolin (LPS + L) compared to untreated mice LPS-induced depression mice (LPS).
| Regulation | KEGG signaling | Genes |
| Upregulation | Parkinson’s disease (mmu05012) | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) (Atp5g3) |
| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D (Atp5h) | ||
| ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (Atp5o) | ||
| ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit (Atp5e) | ||
| ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (Atp5c1) | ||
| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 (Ndufa13) | ||
| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 (Ndufa3) | ||
| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 (Ndufa9) | ||
| NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11 (Ndufb11) | ||
| NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 (Ndufb5) | ||
| NADH dehydrogenase (ubiquinone) flavoprotein 3 (Ndufv3) | ||
| NADH dehydrogenase [ubiquinone] 1 subunit C2 (LOC102641347) | ||
| NADH dehydrogenase subunit 5 (ND5) | ||
| cytochrome c oxidase subunit IV isoform 1 (Cox4i1) | ||
| cytochrome c oxidase subunit VIIa 2 (Cox7a2) | ||
| cytochrome c oxidase subunit VIIa polypeptide 2-like (Cox7a2l) | ||
| cytochrome c oxidase subunit VIa polypeptide 1 (Cox6a1) | ||
| cytochrome c oxidase subunit Va (Cox5a) | ||
| cytochrome c oxidase subunit Vb (Cox5b) | ||
| cytochrome c oxidase, subunit VIb polypeptide 1 (Cox6b1) | ||
| guanine nucleotide binding protein (G protein), alpha inhibiting 2 (Gnai2) | ||
| solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 (Slc25a4) | ||
| solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 (Slc25a5) | ||
| ubiquinol-cytochrome c reductase binding protein (Uqcrb) | ||
|
| ||
| Alzheimer’s disease (mmu05010) | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D (Atp5h) | |
| ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (Atp5o) | ||
| ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit (Atp5e) | ||
| ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (Atp5c1) | ||
| ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (Atp2a2) | ||
| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D (Atp5h) | ||
| ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (Atp5o) | ||
| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 (Ndufa13) | ||
| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 (Ndufa3) | ||
| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 (Ndufa9) | ||
| NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11 (Ndufb11) | ||
| NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 (Ndufb5) | ||
| NADH dehydrogenase (ubiquinone) flavoprotein 3 (Ndufv3) | ||
| NADH dehydrogenase [ubiquinone] 1 subunit C2 (LOC102641347) | ||
| amyloid beta (A4) precursor protein (App) | ||
| apolipoprotein E (Apoe) | ||
| calmodulin 1 (Calm1) | ||
| cytochrome c oxidase subunit IV isoform 1 (Cox4i1) | ||
| cytochrome c oxidase subunit VIIa 2 (Cox7a2) | ||
| cytochrome c oxidase subunit VIIa polypeptide 2-like (Cox7a2l) | ||
| cytochrome c oxidase subunit VIa polypeptide 1 (Cox6a1) | ||
| cytochrome c oxidase subunit Va (Cox5a) | ||
| cytochrome c oxidase subunit Vb (Cox5b) | ||
| cytochrome c oxidase, subunit VIb polypeptide 1 (Cox6b1) | ||
| glyceraldehyde-3-phosphate dehydrogenase, pseudogene 15 (Gapdh-ps15) | ||
| presenilin enhancer gamma secretase subunit (Psenen) | ||
| ubiquinol-cytochrome c reductase binding protein (Uqcrb) | ||
|
| ||
| Huntington’s disease (mmu05016) | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) (Atp5g3) | |
| ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D (Atp5h) | ||
| ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (Atp5o) | ||
| ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit (Atp5e) | ||
| ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (Atp5c1) | ||
| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 (Ndufa13) | ||
| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 (Ndufa3) | ||
| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 (Ndufa9) | ||
| NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11 (Ndufb11) | ||
| NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 (Ndufb5) | ||
| NADH dehydrogenase (ubiquinone) flavoprotein 3 (Ndufv3) | ||
| NADH dehydrogenase [ubiquinone] 1 subunit C2 (LOC102641347) | ||
| cAMP responsive element binding protein 3 (Creb3) | ||
| clathrin, light polypeptide (Lca) (Clta) | ||
| cytochrome c oxidase subunit IV isoform 1 (Cox4i1) | ||
| cytochrome c oxidase subunit VIIa 2 (Cox7a2) | ||
| cytochrome c oxidase subunit VIIa polypeptide 2-like (Cox7a2l) | ||
| cytochrome c oxidase subunit VIa polypeptide 1 (Cox6a1) | ||
| cytochrome c oxidase subunit Va (Cox5a) | ||
| cytochrome c oxidase subunit Vb (Cox5b) | ||
| cytochrome c oxidase, subunit VIb polypeptide 1 (Cox6b1) | ||
| dynactin 1 (Dctn1) | ||
| solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 (Slc25a4) | ||
| solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 (Slc25a5) | ||
| superoxide dismutase 1, soluble (Sod1) | ||
| ubiquinol-cytochrome c reductase binding protein (Uqcrb) | ||
|
| ||
| Upregulation | Estrogen signaling pathway (mmu04915) | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas) |
| cAMP responsive element binding protein 3 (Creb3) | ||
| calmodulin 1 (Calm1) | ||
| guanine nucleotide binding protein (G protein), alpha inhibiting 2 (Gnai2) | ||
| heat shock protein 1B (Hspa1b) | ||
| heat shock protein 8 (Hspa8) | ||
| heat shock protein 90 alpha (cytosolic), class B member 1 (Hsp90ab1) | ||
| heat shock protein 90, alpha (cytosolic), class A member 1 (Hsp90aa1) | ||
| heat shock protein 90, beta (Grp94), member 1 (Hsp90b1) | ||
| phosphatidylinositol 3-kinase catalytic delta polypeptide (Pik3cd) | ||
|
| ||
| Thyroid hormone signaling pathway (mmu4919) | ATPase, Na+/K+ transporting, alpha 2 polypeptide (Atp1a2) | |
| ATPase, Na+/K+ transporting, beta 2 polypeptide (Atp1b2) | ||
| actin, beta (Actb) | ||
| actin, gamma, cytoplasmic 1 (Actg1) | ||
| catenin (cadherin associated protein), beta 1 (Ctnnb1) | ||
| phosphatidylinositol 3-kinase catalytic delta polypeptide (Pik3cd) | ||
| phospholipase C, gamma 1 (Plcg1) | ||
| solute carrier family 16 (monocarboxylic acid transporters), member 2 (Slc16a2) | ||
| solute carrier family 2 (facilitated glucose transporter), member 1 (Slc2a1) | ||
| solute carrier organic anion transporter family, member 1c1 (Slco1c1) | ||
|
| ||
| HIF-1 signaling pathway (04066) | FMS-like tyrosine kinase 1 (Flt1) | |
| Enolase 1, alpha non-neuron (Eno1) | ||
| Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 15 (Gapdh-ps15) | ||
| phosphatidylinositol 3-kinase catalytic delta polypeptide (Pik3cd) | ||
| phospholipase C, gamma 1 (Plcg1) | ||
| predicted gene 9840 (Gm9840) | ||
| ribosomal protein S6 (Rps6) | ||
| solute carrier family 2 (facilitated glucose transporter), member 1 (Slc2a1) | ||
| transferrin receptor (Tfrc) | ||
|
| ||
| Glycolysis/Gluconeogenesis (mmu00010) | aldo-keto reductase family 1, member A1 (aldehyde reductase) (Akr1a1) | |
| aldolase A, fructose-bisphosphate (Aldoa) | ||
| aldolase C, fructose-bisphosphate (Aldoc) | ||
| enolase 1, alpha non-neuron (Eno1) | ||
| glucose phosphate isomerase 1 (Gpi1) | ||
| glyceraldehyde-3-phosphate dehydrogenase, pseudogene 15 (Gapdh-ps15) | ||
| lactate dehydrogenase B (Ldhb) | ||
|
| ||
| Adherens junction (mmu04520) | actin, beta (Actb) | |
| actin, gamma, cytoplasmic 1 (Actg1) | ||
| catenin (cadherin associated protein), alpha 1 (Ctnna1) | ||
| catenin (cadherin associated protein), beta 1 (Ctnnb1) | ||
| cell division cycle 42 (Cdc42) | ||
| protein tyrosine phosphatase, receptor type, B (Ptprb) | ||
| sorbin and SH3 domain containing 1 (Sorbs1) | ||
|
| ||
| Downregulation | Systemic lupus erythematous (mmu05322) | H2A histone family, member Z (H2afz) |
| cathepsin G (Ctsg) | ||
| histone cluster 1, H2ac (Hist1h2ac) | ||
Gene abbreviations are indicated in bold.