TABLE 3.
Top significantly enriched KEGG signaling pathways in Hippocampus of LPS-induced depression mice (LPS) compared to untreated normal mice (PBS).
| Regulation | KEGG signaling | Genes |
| Upregulation | Hematopoietic cell lineage (mmu04640) | CD44 antigen (Cd44) |
| Fc receptor, IgG, high affinity I (Fcgr1) | ||
| colony stimulating factor 1 receptor (Csf1r) | ||
| histocompatibility 2, class II antigen E beta (H2-Eb1) | ||
| sialic acid binding Ig-like lectin H (Siglech) | ||
|
| ||
| Cell adhesion molecules (CAMs) (mmu04514) | H-2 class I histocompatibility antigen, K-D alpha chain (LOC101056305) | |
| cadherin 15 (Cdh15) | ||
| contactin 2 (Cntn2) | ||
| golgi apparatus protein 1 (Glg1) | ||
| histocompatibility 2, K1, K region (H2-K1) | ||
| histocompatibility 2, Q region locus 6 (H2-Q6) | ||
| histocompatibility 2, class II antigen E beta (H2-Eb1) | ||
|
| ||
| Tuberculosis (mmu05152) | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74) | |
| Fc receptor, IgE, high affinity I, gamma polypeptide (Fcer1g) | ||
| Fc receptor, IgG, high affinity I (Fcgr1) | ||
| Fc receptor, IgG, low affinity III (Fcgr3) | ||
| apoptotic peptidase activating factor 1 (Apaf1) | ||
| calcium/calmodulin-dependent protein kinase II, delta (Camk2d) | ||
| cathepsin S (Ctss) | ||
| histocompatibility 2, class II antigen E beta (H2-Eb1) | ||
|
| ||
| Antigen processing and presentation (mmu04612) | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74) | |
| H-2 class I histocompatibility antigen, K-D alpha chain (LOC101056305) | ||
| beta-2 microglobulin (B2m) | ||
| cathepsin S (Ctss) | ||
| histocompatibility 2, K1, K region (H2-K1) | ||
| histocompatibility 2, Q region locus 6 (H2-Q6) | ||
| histocompatibility 2, class II antigen E beta (H2-Eb1) | ||
Gene abbreviations are indicated in bold.