TABLE 4.
Top significantly enriched KEGG signaling pathways in Hippocampus of LPS-induced depression mice treated with luteolin (LPS + L) compared to untreated LPS-induced depression mice (LPS).
| Regulation | KEGG signaling | Genes |
| Upregulation | PI3K-Akt signaling pathway (mmu04151) | collagen, type II, alpha 1 (Col2a1) |
| epidermal growth factor receptor (Egfr) | ||
| fibroblast growth factor 18 (Fgf18) | ||
| interleukin 4 receptor, alpha (Il4ra) | ||
| laminin, alpha 5 (Lama5) | ||
| phosphoinositide-3-kinase, catalytic, gamma polypeptide (Pik3cg) | ||
| prolactin receptor (Prlr) | ||
| retinoid X receptor alpha (Rxra) | ||
| ribosomal protein S6 (Rps6) | ||
|
| ||
| Cytokine-cytokine receptor interaction (mmu04060) | RELT tumor necrosis factor receptor (Relt) | |
| chemokine (C-C motif) receptor 2 (Ccr2) | ||
| ectodysplasin-A (Eda) | ||
| inhibin beta-B (Inhbb) | ||
| Interleukin 17 receptor A (Il17ra) | ||
| Interleukin 4 receptor, alpha (Il4ra) | ||
| prolactin receptor (Prlr) | ||
|
| ||
| Serotonergic synapse (mmu04726) | 5-hydroxytryptamine (serotonin) receptor 5B (Htr5b) | |
| GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas) | ||
| arachidonate 12-lipoxygenase (Alox12) | ||
| arachidonate 15-lipoxygenase (Alox15) | ||
| arachidonate 8-lipoxygenase (Alox8) | ||
|
| ||
| Jak-STAT signaling pathway (mmu04630) | CREB binding protein (Crebbp) | |
| interleukin 4 receptor, alpha (Il4ra) | ||
| phosphoinositide-3-kinase, catalytic, gamma polypeptide (Pik3cg) | ||
| prolactin receptor (Prlr) | ||
| signal transducer and activator of transcription 5B (Stat5b) | ||
|
| ||
| Estrogen signaling pathway (mmu04915) | FK506 binding protein 4 (Fkbp4) | |
| GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus (Gnas) | ||
| epidermal growth factor receptor (Egfr) | ||
| phosphoinositide-3-kinase, catalytic, gamma polypeptide (Pik3cg) | ||
|
| ||
| Downregulation | Fatty acid metabolism (mmu01212) | ELOVL family member 5, elongation of long chain fatty acids (yeast) (Elovl5) |
| acetyl-Coenzyme A acyltransferase 1A (Acaa1a) | ||
| acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) (Acaa2) | ||
| acyl-CoA synthetase long-chain family member 3 (Acsl3) | ||
| acyl-Coenzyme A dehydrogenase, long-chain (Acadl) | ||
| elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2) | ||
| fatty acid desaturase 2 (Fads2) | ||
|
| ||
| Biosynthesis of unsaturated fatty acids (mmu01040) | ELOVL family member 5, elongation of long chain fatty acids (yeast) (Elovl5) | |
| acetyl-Coenzyme A acyltransferase 1A (Acaa1a) | ||
| acyl-CoA thioesterase 1 (Acot1) | ||
| elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2) | ||
| fatty acid desaturase 2 (Fads2) | ||
|
| ||
| GABAergic synapse (mmu04727) | gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 (Gabrb3) | |
| gephyrin (Gphn) | ||
| glutamate decarboxylase 1 (Gad1) | ||
| glutamate-ammonia ligase (glutamine synthetase) (Glul) | ||
| guanine nucleotide binding protein (G protein), alpha inhibiting 3 (Gnai3) | ||
| guanine nucleotide binding protein (G protein), beta 1 (Gnb1) | ||
| guanine nucleotide binding protein (G protein), gamma 2 (Gng2) | ||
| protein kinase, cAMP dependent, catalytic, beta (Prkacb) | ||
Gene abbreviations are indicated in bold.