Table 2.

MCCB total and subscale scores at baseline and weeks 4, 8, and 12 in the betahistine and placebo groups.

	Betahistine group	Placebo group	Time F (p-value)	Group F (p-value)	Group*Time F (p-value)
Speed of processing			20.33 (<0.01)	3.19 (0.08)	2.27 (0.10)
Baseline	42.63 ± 10.95	40.66 ± 10.33
Week 4	46.05 ± 10.67	41.61 ± 10.82
Week 8	46.40 ± 10.32	41.93 ± 10.48
Week 12	48.56 ± 10.57	43.98 ± 10.00
Attention/Vigilance			2.25 (0.10)	3.43 (0.07)	2.23 (0.10)
Baseline	44.30 ± 11.21	42.27 ± 11.71
Week 4	47.74 ± 10.70	42.41 ± 10.65
Week 8	46.47 ± 10.15	41.95 ± 11.89
Week 12	46.42 ± 10.66	41.64 ± 11.46
Working memory			17.32 (<0.01)	3.3 (0.10)	2.39 (0.08)
Baseline	45.35 ± 14.59	43.70 ± 12.51
Week 4	51.37 ± 12.26	45.52 ± 13.64
Week 8	52.05 ± 11.48	46.93 ± 12.40
Week 12	53.09 ± 9.84	47.73 ± 12.26
Verbal learning			11.05 (<0.01)	3.08 (0.08)	3.44 (0.02)
Baseline	43.26 ± 9.51	41.93 ± 14.41
Week 4	45.47 ± 8.07	42.27 ± 12.86
Week 8	47.49 ± 9.89	43.48 ± 12.84
Week 12	51.16 ± 9.89	44.05 ± 12.91
Visual learning			11.05 (<0.01)	2.81 (0.10)	6.07 (0.001)
Baseline	37.60 ± 9.11	38.52 ± 12.81
Week 4	42.26 ± 11.60	37.70 ± 11.28
Week 8	43.93 ± 11.38	39.34 ± 11.33
Week 12	46.19 ± 11.8	39.82 ± 10.35
Reasoning and problem solving			11.92 (<0.01)	6.19 (0.01)	0.86 (0.46)
Baseline	46.35 ± 12.95	41.52 ± 10.99
Week 4	46.77 ± 10.37	39.95 ± 12.38
Week 8	48.42 ± 10.7	43.55 ± 9.86
Week 12	49.84 ± 10.77	45.5 ± 10.48
Social cognition			0.17 (0.90)	0.73 (0.40)	0.91 (0.43)
Baseline	41.49 ± 10.31	40.48 ± 11.78
Week 4	41.63 ± 12.07	41.50 ± 10.6
Week 8	42.58 ± 12.13	39.77 ± 10.36
Week 12	43.19 ± 12.26	40.09 ± 10.08
MCCB total score			27.5 (<0.01)	4.72 (0.03)	5.32 (0.003)
Baseline	40.51 ± 11.40	38.05 ± 13.07
Week 4	44.44 ± 10.38	38.64 ± 12.37
Week 8	45.60 ± 10.79	39.80 ± 11.65
Week 12	47.77 ± 10.51	41.00 ± 11.75

MCCB, MATRICS Consensus Cognitive Battery; Bold value means Group*Time p < 0.05.