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. 2021 Nov 1;9:720925. doi: 10.3389/fcell.2021.720925

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Copyright © 2021 Jiang, Zhu, Huang, Zhao, Zhang, An, Liao, Guo, Liu, Zhou and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methyltransferase-like 3 regulates angiogenesis and DO regeneration responses. (A,B) Representative 3D and longitudinal images (A) and quantitative analysis (B) of micro-CT data, including bone mineral density (BMD), bone volume/tissue volume (BV/TV), trabecular separation (Tb. Sp), trabecular number (Tb. N), and trabecular thickness (Tb. Th) of the mandibular distraction area after 4 weeks of consolidation. (C,D) For histological analyses, H&E (C) and Masson’s trichrome (D) staining of the MDO callus were performed in the different groups. (E) IHC assessment of OCN in the NC-OE and OE-METTL3 groups. NC-OE and OE-METTL3 groups were compared via Student’s t-tests. Arrows, extracellular matrix. M, Mandible, NT, Newly formed trabecula. Scale bars: 100 and 500 μm. *P < 0.05, **P < 0.01, ***P < 0.001 vs. NC-OE; n = 3 canine in each group.