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. 2021 Nov 1;13:753351. doi: 10.3389/fnagi.2021.753351

FIGURE 8.

FIGURE 8

Predicted function of the gut microbiota and its correlation with the liver retinol and serum retinol. (A) Comparisons of the VAD- and VAN-diet impact on the predicted functions of the gut microbiota at the Kyoto Encyclopedia of Gene and Genomes (KEGG) level 2 by using the PICRUSt analysis. The number indicates the logarithmic value of enrichment to the pathways. (B) Significantly different functions of the gut microbiota at KEGG level 3 between the VAN and VAD group as predicted by the PICRUSt analysis (partial). (C) Correlation of the liver retinol and the serum retinol with the relative abundance of the top 50 bacterial genera in all mice. The red color represents a positive correlation. Blue color represents a negative correlation. VAD, vitamin A deficiency diet; VAN, vitamin A normal diet. n = 10 per group. P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.

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